Pharmacokinetics of levamisole in rabbits after intravenous administration
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منابع مشابه
Pharmacokinetics of Flunixin-meglumin following Intravenous Administration in Angora Rabbits
The pharmacokinetics of flunixin-meglumin were determined after intravenous bolus injection at two different doses (1.1 and 2.2 mg/kg body weight) in rabbits. Six healthy adult Angora rabbits were used in the experiment. Blood samples were collected at 10, 20, 30, 45 and 60 min, 2, 4, 6, and 8 h after injection. Concentrations of drug in plasma were determined by HPLC. Pharmacokinetics were des...
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BACKGROUND Intrathecal administration of antibiotics has potentially high effectiveness for the treatment for severe intracranial infections, particularly nosocomial meningitis. The use of intrathecal injection of antibiotics has been reported mostly in case reports. However, there is sparse data regarding the pharmacokinetics of antibiotics after intrathecal administration. AIM This study in...
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The aim of this study is to develop a sensitive HPLC method for the quantitative determination of cytisine in serum and to characterize the pharmacokinetic behaviour of cytisine after oral and intravenous administration in rabbits. The pharmacokinetic behaviour of cytisine is studied in male and female New Zealand rabbits after oral and intravenous administration. Cytisine is administered orall...
متن کاملPharmacokinetics of m-nifedipine in rabbits after intravenous injection.
AIM To study the dose effects on pharmacokinetics of m-Nif. METHODS Fifteen rabbits were divided into 3 groups receiving i.v. m-Nif 0.5, 1, and 2 mg.kg-1. Plasma levels of m-Nif were determined with HPLC method. RESULTS The concentration-time data were fitted with 2-compartment model. After i.v. 1 mg.kg-1, the parameters were: Vd = 0.37 +/- 0.10 L.kg-1, T1/2 alpha = 6.4 +/- 2.9 min, T1/2 be...
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ژورنال
عنوان ژورنال: Journal of Veterinary Pharmacology and Therapeutics
سال: 1992
ISSN: 0140-7783,1365-2885
DOI: 10.1111/j.1365-2885.1992.tb00990.x